TB-500 (Thymosin Beta 4) (5mg / 10mg)

Description

TB-500 Peptide: Tissue Repair, Angiogenesis, and Cellular Regeneration

 It is also known as synthetic Thymosin Beta-4 (Tβ4), is a 43-amino-acid peptide derived from the naturally occurring Thymosin beta 4 protein, encoded by the TMSB4X gene. TB-500 is widely studied for its potential in wound healing, angiogenesis, tissue regeneration, anti-inflammatory effects, and hair growth.

This peptide acts through actin binding, cell migration promotion, and modulation of signaling pathways like Notch, NF-κB, and Akt, supporting cell survival, repair, and angiogenesis.

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Chemical Makeup

• Molecular Formula: C212H350N56O78S

• Molecular Weight: 4963 g/mol

• Other Names: Thymosin Beta-4, Tβ4

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Research and Clinical Insights

Inflammation Modulation

• May increase microRNA-146a (miR-146a), regulating IRAK1 and TRAF6, potentially reducing inflammation.

Wound Healing

• Accelerates acute wound repair: up to 41% increase in re-epithelialization in murine models.

• Enhances collagen deposition and wound contraction, supporting faster recovery.

• Accelerates chronic wound healing in diabetic, aged, and steroid-influenced animal models. Phase 2 trials suggested healing improvements up to 1 month faster.

Heart and Cardiac Cells

• Potentially reduces ventricular hypertrophy in pulmonary hypertension models.

• Supports cardiomyocyte survival, angiogenesis, and early cardiac repair via ILK-Akt signaling.

• Promotes cardiac fibroblast differentiation toward cardiomyocyte-like cells and enhances migration of myocardial/endothelial cells.

Hair Follicle Growth

• Increases hair shafts and follicles in murine skin models.

• Elevates mRNA and protein expression associated with hair growth.

Blood Vessel Formation (Angiogenesis)

• Enhances endothelial cell viability, migration, and tube formation.

• Regulates angiogenesis markers such as VEGFA, Ang2, tie2, CD31, α-SMA, via Notch and NF-κB pathways.

• Inhibition studies suggest TB-500 acts specifically through these pathways.

Corneal and Ocular Tissue Repair

• Promotes corneal wound healing and reduces infiltration of neutrophils (PMNs).

• Modulates IL-1β, IL-6, and chemokines, potentially reducing inflammation.

• Exhibits anti-apoptotic activity by blocking caspase activation and activating Akt signaling.

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Key Benefits of TB-500

• Accelerates acute and chronic wound healing

• Promotes angiogenesis and vascular regeneration

• Supports cardiac and corneal tissue repair

• Exhibits anti-inflammatory and anti-apoptotic properties

• May induce hair follicle growth and enhance cellular migration

Please review and adhere to our Terms and Conditions before ordering.

References:

1. Kleinman HK, Sosne G. Thymosin β4 Promotes Dermal Healing. Vitam Horm. 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24.
2. Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.
3. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039. PMID: 18480812.