Receptor Grade IGF-1 LR3 (1mg)

Description

eceptor Grade IGF-1 LR3: Peptide for Muscle Growth, Anabolism, and Tissue Repair

IGF-1 LR3, also known as Long arginine 3 IGF-1 or LR3-IGF-1, is a synthetic insulin-like growth factor analog designed for cellular growth and tissue repair. It is an extended version of natural IGF-1 with 83 amino acids (vs. 70 in IGF-1) and an added arginine at position 3, which gives it higher bioavailability and reduced binding to IGF-binding proteins (IGFBPs). This structural modification allows IGF-1 LR3 to persist longer in the body and interact more effectively with target tissues, including muscle, kidney, adrenal, and reproductive tissues.

IGF-1 LR3 has been studied for its potential to stimulate anabolism, enhance lean muscle mass, support metabolic activity, and promote tissue growth in experimental models. It may act via IGF-1 receptor-dependent or IGF-independent mechanisms, triggering autocrine and paracrine signaling pathways in cells.

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Chemical Makeup

• Molecular Formula: C400H625N111O115S9

• Molecular Weight: 9117.5 g/mol

• Other Names: Long-(Arg3) insulin-like growth factor-I, Insulin-like growth factor long chain R3

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Research and Clinical Insights

IGF-1 LR3 and Tissue Anabolism

Studies suggest it may have superior anabolic potential compared to native IGF-1:

• In murine models, it was ~2.5 times more potent in promoting organ weight gain and muscle growth.

• It reduces Nτ-methylhistidine excretion, a marker of muscle protein breakdown, up to three times more than IGF-1.

• Recombinant IGF-1 (rhIGF-1) studies in humans indicate potential height and tissue growth in IGF-1 deficient models, hinting at similar benefits of LR3 analogs.

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IGF-1 LR3 and Metabolic Activity

it may enhance glucose uptake and metabolism via cellular signaling:

• Activates PI3K/Akt pathway, promoting GLUT4 translocation and glucose entry into cells.

• May influence AMPK signaling, supporting energy balance under stress.

• Reduces myostatin action in muscle, potentially increasing lean mass and reducing fat mass.

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IGF-1 LR3 and Muscle Health

Research indicates IGF-1 LR3 may support muscle growth and repair:

• Counters myostatin, a protein that inhibits muscle differentiation.

• Helps prevent muscle apoptosis and supports muscle cell survival.

• Prolonged activity due to its extended half-life increases tissue exposure, amplifying potential anabolic effects.

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Key Benefits of IGF-1 LR3

• Enhances lean muscle mass and tissue growth

• Supports muscle repair and regeneration

• Promotes glucose metabolism and energy utilization

• Reduces muscle protein breakdown

• Potentially improves organ health and metabolic function

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References:

1. Yakar, S et al., 40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton (Jul 2018). Journal of Molecular Endocrinology, vol. 61 Issue 1. https://doi.org/10.1530/JME-17-0298
2. Growth hormone, athletic performance, and aging. Harvard Health Publishing, Harvard Medical School. https://www.health.harvard.edu/diseases-and-conditions/growth-hormone-athletic-performance-and-aging
3. Tomas, F. M., Knowles, S. E., Owens, P. C., Chandler, C. S., Francis, G. L., Read, L. C., & Ballard, F. J. (1992). Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. The Biochemical journal, 282 ( Pt 1)(Pt 1), 91–97. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1130894/