Description

Pal-GHK Peptide: Collagen, Antioxidation, and Skin Repair

What is Pal-GHK?

Palmitoyl-GHK, also known as Palmitoyl-tripeptide-1, is a synthetic peptide made of three amino acids—Glycine, Histidine, and Lysine—attached to a palmitic acid molecule. The GHK sequence occurs naturally in human plasma, first discovered in 1973 by Pickart et al.

Adding a palmitoyl group enhances lipid solubility, allowing better penetration through the stratum corneum. It may also temporarily disrupt the skin’s lipid barrier, enabling Pal-GHK and other molecules to reach deeper layers of the skin.

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Chemical Makeup

• Molecular Formula: C30H54N6O5

• Molecular Weight: 578.8 g/mol

• Other Names: Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide, Biopeptide-CL

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Pal-GHK and Collagen Synthesis

Pal-GHK may stimulate collagen production, a critical component of the skin’s extracellular matrix (ECM). The Gly-His-Lys tripeptide is released during collagen hydrolysis and acts as a signal for fibroblasts to produce new collagen, elastin, and glycosaminoglycans.

• A 1988 study by Maquart et al. suggested GHK fragments promote in situ tissue repair.

• A placebo-controlled trial of 23 subjects reported a 4% increase in skin thickness after Pal-GHK treatment.

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Pal-GHK and Wrinkle Reduction

Clinical studies indicate that Pal-GHK may improve skin texture and reduce wrinkle depth:

• In a cream-based study with 15 participants, the peptide reportedly reduced wrinkle length, depth, and roughness.

• When combined with Pal-GQPR (Pal-Gly-Gln-Pro-Arg), a tetrapeptide that reduces IL-6, a study of 28 subjects showed apparent reductions in wrinkle depth, volume, density, and area occupied by deep wrinkles.

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Pal-GHK and Antioxidant Activity

 This peptide may neutralize free radicals and reduce oxidative stress, potentially slowing skin aging.

• A 2018 lab study by Sakuma et al. found Pal-GHK suppressed hydroxyl, superoxide, and peroxyl radicals more effectively than carnosine or reduced glutathione.

• The peptide may prevent protein glycation and combat reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive carbonyl species (RCS), protecting lipids, DNA, and proteins.

• It may reduce iron release from ferritin by 87%, limiting lipid peroxidation and preserving cell membrane integrity.

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Pal-GHK and Anti-Inflammatory Action

Pal-GHK may reduce inflammation by inhibiting key signaling pathways:

• Suppresses NF-κB and p38 MAPK, potentially lowering TNF-α and IL-6 production.

• Reduces infiltration of inflammatory cells in murine lung tissue models.

• May alleviate oxidative stress in alveolar epithelial cells via Nrf2 activation, increasing antioxidant protein expression and decreasing ROS levels.

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Summary

Pal-GHK is a versatile peptide that may:

• Stimulate collagen and ECM production

• Reduce wrinkle depth and improve skin texture

• Protect against oxidative damage

• Exhibit anti-inflammatory effects

• Support skin barrier and tissue repair

Please review and adhere to our Terms and Conditions before ordering.

References:

1. Pickart, L., & Thaler, M. M. (1973). Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nature: New biology, 243(124), 85–87.
2. Gorouhi, F., & Maibach, H. I. (2009). Role of peptides in preventing or treating aged skin. International journal of cosmetic science, 31(5), 327-345.
3. Maquart, F. X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J. C., & Borel, J. P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS letters, 238(2), 343–346. https://doi.org/10.1016/0014-5793(88)80509-x
4. Trookman, N. S., Rizer, R. L., Ford, R., Mehta, R., & Gotz, V. (2009). Clinical assessment of a combination lip treatment to restore moisturization and fullness. The Journal of clinical and aesthetic dermatology, 2(12), 44–48.
5. Lintner, K., & Peschard, O. (2000). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International journal of cosmetic science, 22(3), 207–218. https://doi.org/10.1046/j.1467-2494.2000.00010.x