Description

ARA-290 Peptide (Cibinetide / HBSP)

Support Tissue Repair, Anti-Inflammation & Cellular Protection

ARA-290 Peptide, also known as cibinetide or helix B surface peptide (HBSP), is an 11-amino-acid peptide derived from the beta domain of erythropoietin (EPO). Unlike EPO, ARA-290 does not stimulate red blood cell production but may support tissue regeneration, reduce inflammation, and protect cells from injury. Researchers suggest it binds to the tissue-protective receptor (TPR), potentially activating the innate repair receptor pathway and promoting cellular survival after tissue damage.

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How ARA-290 Peptide Works

ARA-290 may target TRPV1 nociceptive channels, reducing pain signaling and nerve sensitivity. It also appears to protect endothelial cells, promote vascular repair, and enhance the survival of transplanted cells under inflammatory stress. By engaging the TPR pathway, ARA-290 may modulate immune response, reduce pro-inflammatory cytokines, and support tissue protection without cardiovascular side effects.

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Research Applications

Anti-Nociception and Pain Relief

Studies suggest ARA-290 may inhibit nociception by modulating TRPV1 channels in sensory neurons. This action may increase the pain threshold, potentially reducing discomfort in injury and inflammatory conditions.

Tissue Regeneration and Protection

ARA-290 may enhance tissue repair by activating the innate repair receptor (IRR) pathway, protecting cells from oxidative stress and supporting recovery in damaged tissues, including the retina and pancreatic islets.

Anti-Inflammatory and Immunomodulatory Effects

Research indicates ARA-290 may reduce pro-inflammatory cytokines like IL-6, IL-12, and TNF-α, helping prevent immune-mediated tissue damage. The peptide may also fine-tune adaptive immunity, which could improve transplant acceptance in lab models.

Retinal and Vascular Support

ARA-290 shows potential in supporting endothelial colony-forming cells (ECFCs) in ischemic retinal models, enhancing vascular repair and reducing inflammation, possibly benefiting studies on retinal ischemia.

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Chemical Makeup

• Molecular Formula: C51H54N16O21

• Molecular Weight: 1257.3 g/mol

• Other Names: PH-BSP, Cibinetide, Helix B Surface Peptide

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References:

1. What is Erythropoietin? Home Health Network. https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/erythropoietin
2. Brines M, Cerami A. The receptor that tames the innate immune response. Mol Med. 2012 May 9;18(1):486-96. https://pubmed.ncbi.nlm.nih.gov/22183892/
3. Dahan, A., Dunne, A., Swartjes, M., Proto, P. L., Heij, L., Vogels, O., van Velzen, M., Sarton, E., Niesters, M., Tannemaat, M. R., Cerami, A., & Brines, M. (2013). ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density. Molecular medicine (Cambridge, Mass.), 19(1), 334–345. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883966/