MGF IGF-1 EC (5mg)

Description

MGF IGF-1 Ec Peptide: Muscle, Bone, and Cartilage Support

MGF IGF-1 Ec, or Mechano-Growth Factor C-terminal 24 (MGF-Ct24E), is a 24-amino-acid fragment cleaved from IGF-1 Ec. Unlike full-length IGF-1, MGF IGF-1 Ec bypasses classical IGF-1 receptor activation, signaling primarily through ERK pathways. It has been extensively studied for muscle hypertrophy, tissue repair, anti-apoptotic activity, and bone regeneration.

This peptide is a research tool for understanding noncanonical IGF-1 signaling, particularly in muscle, cartilage, bone, and neural-like cells, and offers potential for investigating cell survival, regeneration, and stress response mechanisms.

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Chemical Makeup

• Molecular Formula: C124H204N42O41S1

• Molecular Weight: 2971.99 g/mol

• Other Names: Mechano-Growth Factor, MGF-Ct24E

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Research and Clinical Insights

Muscle Cell Hypertrophy & Growth

• Activates Erk1/2 and Erk5, promoting muscle cell hypertrophy without IGF-1 receptor tyrosine phosphorylation.

• Increases cell volume and protein content in smooth muscle and myoblast cultures.

• Supports Erk5–MEF2C–dependent gene expression, enhancing α-smooth muscle actin, γ-actin, smoothelin, and desmin.

Muscle Cell Aging & Regeneration

• May mitigate aging in young satellite cells, prolonging division cycles in vitro.

• Effects are age-dependent, with limited benefit in older cells.

Anti-Fibrotic & Anti-Inflammatory Action

• Reduces muscle fibrosis, early collagen I/III expression, and pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, TGF-β).

• Modulates oxidative stress (gp91phox) and matrix metalloproteinases (MMP-1, 2, 9, 10, 14).

Anti-Apoptotic & Cell Survival

• Enhances Bcl-2 expression and reduces DNA fragmentation in hypoxic muscle cells.

• Preserves mitochondrial integrity, supporting intrinsic survival pathways.

Cartilage & Chondrocyte Support

• Potentiates TGF-β3-induced chondrogenesis, favoring Col2 and aggrecan expression.

• Reduces Col1 and pro-fibrotic markers in damaged cartilage.

• Supports cell migration and cytoskeletal organization via RhoA–YAP pathways.

Bone Cell & Osteoanabolic Activity

• Stimulates osteoblast proliferation, increasing S and G2/M phase cell populations.

• Acts through ERK1/2 signaling, independent of IGF-1 receptor.

• Promotes callus formation, cortical bridging, lamellar bone formation, and early fracture healing.

Neural-Like Cell Protection

• Enhances survival in SH-SY5Y neuroblastoma cells under mitochondrial stress.

• Reduces apoptosis and preserves mitochondrial function.

• Mechanism linked to HO-1 upregulation and ERK pathway activation.

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Key Benefits of MGF IGF-1 Ec

• Supports muscle hypertrophy and regeneration

• Promotes bone formation and osteoblast proliferation

• Enhances cartilage repair and chondrocyte function

• Reduces fibrosis, oxidative stress, and inflammation

• Protects neural-like cells and supports cell survival under stress

Please review our Terms and Conditions before ordering.

References:

1. Janssen JA, Hofland LJ, Strasburger CJ, van den Dungen ES, Thevis M. Potency of Full-Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations. PLoS One. 2016 Mar 18;11(3):e0150453. doi: 10.1371/journal.pone.0150453. PMID: 26991004; PMCID: PMC4798685.
2. Li C, Vu K, Hazelgrove K, Kuemmerle JF. Increased IGF-IEc expression and mechano-growth factor production in the intestinal muscle of fibrostenotic Crohn’s disease and smooth muscle hypertrophy. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G888-99. doi: 10.1152/ajpgi.00414.2014. Epub 2015 Oct 1. PMID: 26428636; PMCID: PMC4669353.
3. Kandalla PK, Goldspink G, Butler-Browne G, Mouly V. Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages. Mech Ageing Dev. 2011 Apr;132(4):154-62. doi: 10.1016/j.mad.2011.02.007. Epub 2011 Feb 25. PMID: 21354439.
4. Liu X, Zeng Z, Zhao L, Chen P, Xiao W. Impaired Skeletal Muscle Regeneration Induced by Macrophage Depletion Could Be Partly Ameliorated by MGF Injection. Front Physiol. 2019 May 17;10:601. PMID: 31164836; PMCID: PMC6534059.doi:10.3389/fphys.2019.00601