Matrixyl (200mg)

Description

Matrixyl Peptide: Collagen-Boosting Peptide for Wrinkles and Skin Repair

Matrixyl, also known as palmitoyl pentapeptide-4 (formerly palmitoyl pentapeptide-3), is a synthetic peptide designed to stimulate collagen production in the skin. Classified as a matrikine, Matrixyl may act as a messenger peptide, signaling cells to regulate skin renewal and repair. Collagen provides structural support and flexibility to the skin’s extracellular matrix (ECM). The palmitoyl conjugation enhances skin penetration and protects the peptide from degradation, allowing more consistent delivery and longer-lasting effects.

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Chemical Makeup

• Molecular Formula: C39H75N7O10

• Molecular Weight: 802.05 g/mol

• Other Names: Palmitoyl pentapeptide-4, Palmitoyl pentapeptide-3 (pre-2006)

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Research and Clinical Insights

Matrixyl and Collagen Synthesis

Matrixyl may act as a signal peptide fragment from type I collagen, interacting with fibroblasts to stimulate new collagen and ECM protein production. Fibroblasts are crucial cells in connective tissue that maintain the ECM by producing collagen, elastin, laminin, and fibronectin. Research indicates that Matrixyl can promote collagen synthesis in a concentration-dependent manner, suggesting that self-assembly of peptides enhances collagen formation through hydrogen bonds, electrostatic interactions, hydrophobic interactions, π–π stacking, and van der Waals forces.

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Matrixyl and Wrinkle Reduction

Clinical studies suggest that Matrixyl may reduce wrinkle depth and improve skin texture. For example:

• In double-blind trials, bilateral exposure to Matrixyl showed visible wrinkle reduction compared to placebo.

• Daily application for 8 weeks in the periorbital area improved skin texture and reduced wrinkle depth more effectively than control peptides or placebo.

• Another study reported significant improvements in periorbital wrinkles and skin smoothness after 4 weeks of Matrixyl use.

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Matrixyl and Scarring

It may help prevent fibrotic scarring by regulating fibroblast activity:

• It reportedly reduces α-SMA expression, a protein linked to myofibroblast activation.

• By inhibiting fibroblast-to-myofibroblast trans-differentiation, Matrixyl may limit excessive collagen deposition, reducing scar formation and promoting healthier tissue repair.

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Matrixyl and Tissue Repair

Animal studies indicate that Matrixyl may enhance wound healing:

• In treated groups, wound healing improved from 63.5% to 81.8%, especially at higher Matrixyl concentrations.

• Conjugates of Matrixyl with imidazolium-based ionic liquids showed collagen-inducing and antimicrobial properties, further supporting tissue repair and regeneration.

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References:

1. Choi, Y. L., Park, E. J., Kim, E., Na, D. H., & Shin, Y. H. (2014). Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS). Biomolecules & therapeutics, 22(4), 321–327. https://doi.org/10.4062/biomolther.2014.053
2. Errante, F., Ledwoń, P., Latajka, R., Rovero, P., & Papini, A. M. (2020). Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Frontiers in chemistry, 8, 572923. https://doi.org/10.3389/fchem.2020.572923
3. Jones, R. R., Castelletto, V., Connon, C. J., & Hamley, I. W. (2013). Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Molecular pharmaceutics, 10(3), 1063–1069. https://doi.org/10.1021/mp300549d